Topical Melatonin Improves Gastric Microcirculatory Oxygenation During Hemorrhagic Shock in Dogs but Does Not Alter Barrier Integrity of Caco-2 Monolayers

Topical Melatonin Improves Gastric Microcirculatory Oxygenation During Hemorrhagic Shock in Dogs but Does Not Alter Barrier Integrity of Caco-2 Monolayers

Systemic administration of melatonin exerts tissue protective effects in the context of hemorrhagic shock. Intravenous application of melatonin prior to hemorrhage improves gastric microcirculatory perfusion and maintains intestinal barrier function in dogs. The aim of the present study was to analy...

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Bibliographic Details
Main Authors: Richard Truse, Inga Nolten, Jan Schulz, Anna Herminghaus, Tobias Holtmanns, Lukas Gördes, Annika Raupach, Inge Bauer, Olaf Picker, Christian Vollmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Medicine
Subjects:
gastric microcirculation
μHbO2
melatonin
hemorrhagic shock
Caco-2 monolayer
mucosal barrier integrity
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00510/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2020.00510/full

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