RAD51 as a biomarker for homologous recombination deficiency in high‐grade serous ovarian carcinoma: robustness and interobserver variability of the RAD51 test

RAD51 as a biomarker for homologous recombination deficiency in high‐grade serous ovarian carcinoma: robustness and interobserver variability of the RAD51 test

Abstract The RAD51 test is emerging as a promising biomarker for the assessment of functional homologous recombination deficiency (HRD). Yet, the robustness and reproducibility of the immunofluorescence‐based RAD51 test, in different academic laboratories, have not been systematically investigated....

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Bibliographic Details
Main Authors: Claire JH Kramer, Alba Llop‐Guevara, Elisa Yaniz‐Galende, Benedetta Pellegrino, Natalja T terHaar, Andrea Herencia‐Ropero, Nicoletta Campanini, Antonino Musolino, Tjalling Bosse, Alexandra Leary, Violeta Serra, Maaike PG Vreeswijk
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:The Journal of Pathology: Clinical Research
Subjects:
analytical validation
biomarker
high‐hrade serous ovarian carcinoma
homologous recombination deficiency
interobserver variability
RAD51 test
Online Access:https://doi.org/10.1002/cjp2.336

Internet

https://doi.org/10.1002/cjp2.336

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