Wound Healing Effect of Supercritical Carbon Dioxide <i>Datura metel</i> L. Leaves Extracts: An In Vitro Study of Anti-Inflammation, Cell Migration, MMP-2 Inhibition, and the Modulation of the Sonic Hedgehog Pathway in Human Fibroblasts

Wound Healing Effect of Supercritical Carbon Dioxide <i>Datura metel</i> L. Leaves Extracts: An In Vitro Study of Anti-Inflammation, Cell Migration, MMP-2 Inhibition, and the Modulation of the Sonic Hedgehog Pathway in Human Fibroblasts

<i>Datura metel</i> L. (thorn apple) has been used in Thai folk wisdom for wound care. In this study, we chose supercritical carbon dioxide extraction (scCO<sub>2</sub>) to develop crude extraction from the leaves of the thorn apple. The phytochemical profiles were observed u...

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Bibliographic Details
Main Authors: Warintorn Ruksiriwanich, Pichchapa Linsaenkart, Anurak Muangsanguan, Korawan Sringarm, Pensak Jantrawut, Chaiwat Arjin, Sarana Rose Sommano, Yuthana Phimolsiripol, Francisco J. Barba
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Plants
Subjects:
<i>Datura metel</i>
cell migration
sonic hedgehog pathway
stimulation of collagen synthesis
supercritical carbon dioxide extraction
wound healing
Online Access:https://www.mdpi.com/2223-7747/12/13/2546

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https://www.mdpi.com/2223-7747/12/13/2546

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