The function and clinical implication of YTHDF1 in the human system development and cancer
Abstract YTHDF1 is a well-characterized m6A reader protein that is essential for protein translation, stem cell self-renewal, and embryonic development. YTHDF1 regulates target gene expression by diverse molecular mechanisms, such as promoting protein translation or modulating the stability of mRNA....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-023-00452-1 |
| _version_ | 1797945849214402560 |
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| author | Wenjun Ren Yixiao Yuan Yongwu Li Luciano Mutti Jun Peng Xiulin Jiang |
| author_facet | Wenjun Ren Yixiao Yuan Yongwu Li Luciano Mutti Jun Peng Xiulin Jiang |
| author_sort | Wenjun Ren |
| collection | DOAJ |
| description | Abstract YTHDF1 is a well-characterized m6A reader protein that is essential for protein translation, stem cell self-renewal, and embryonic development. YTHDF1 regulates target gene expression by diverse molecular mechanisms, such as promoting protein translation or modulating the stability of mRNA. The cellular levels of YTHDF1 are precisely regulated by a complicated transcriptional, post-transcriptional, and post-translational network. Very solid evidence supports the pivotal role of YTHDF1 in embryonic development and human cancer progression. In this review, we discuss how YTHDF1 influences both the physiological and pathological biology of the central nervous, reproductive and immune systems. Therefore we focus on some relevant aspects of the regulatory role played by YTHDF1 as gene expression, complex cell networking: stem cell self-renewal, embryonic development, and human cancers progression. We propose that YTHDF1 is a promising future cancer biomarker for detection, progression, and prognosis. Targeting YTHDF1 holds therapeutic potential, as the overexpression of YTHDF1 is associated with tumor resistance to chemotherapy and immunotherapy. |
| first_indexed | 2024-04-10T21:01:38Z |
| format | Article |
| id | doaj.art-fbad8587d77d4de8b8242914ea2eab6d |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-04-10T21:01:38Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-fbad8587d77d4de8b8242914ea2eab6d2023-01-22T12:20:32ZengBMCBiomarker Research2050-77712023-01-0111111310.1186/s40364-023-00452-1The function and clinical implication of YTHDF1 in the human system development and cancerWenjun Ren0Yixiao Yuan1Yongwu Li2Luciano Mutti3Jun Peng4Xiulin Jiang5Department of Cardiovascular Surgery, The First People’s Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and TechnologyKey Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiovascular Surgery, The First People’s Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and TechnologySbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple UniversityDepartment of Cardiovascular Surgery, The First People’s Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and TechnologyKunming College of Life Science, University of Chinese Academy of SciencesAbstract YTHDF1 is a well-characterized m6A reader protein that is essential for protein translation, stem cell self-renewal, and embryonic development. YTHDF1 regulates target gene expression by diverse molecular mechanisms, such as promoting protein translation or modulating the stability of mRNA. The cellular levels of YTHDF1 are precisely regulated by a complicated transcriptional, post-transcriptional, and post-translational network. Very solid evidence supports the pivotal role of YTHDF1 in embryonic development and human cancer progression. In this review, we discuss how YTHDF1 influences both the physiological and pathological biology of the central nervous, reproductive and immune systems. Therefore we focus on some relevant aspects of the regulatory role played by YTHDF1 as gene expression, complex cell networking: stem cell self-renewal, embryonic development, and human cancers progression. We propose that YTHDF1 is a promising future cancer biomarker for detection, progression, and prognosis. Targeting YTHDF1 holds therapeutic potential, as the overexpression of YTHDF1 is associated with tumor resistance to chemotherapy and immunotherapy.https://doi.org/10.1186/s40364-023-00452-1YTHDF1Embryonic developmentStem cellSelf-renewalTumorBiomarker |
| spellingShingle | Wenjun Ren Yixiao Yuan Yongwu Li Luciano Mutti Jun Peng Xiulin Jiang The function and clinical implication of YTHDF1 in the human system development and cancer Biomarker Research YTHDF1 Embryonic development Stem cell Self-renewal Tumor Biomarker |
| title | The function and clinical implication of YTHDF1 in the human system development and cancer |
| title_full | The function and clinical implication of YTHDF1 in the human system development and cancer |
| title_fullStr | The function and clinical implication of YTHDF1 in the human system development and cancer |
| title_full_unstemmed | The function and clinical implication of YTHDF1 in the human system development and cancer |
| title_short | The function and clinical implication of YTHDF1 in the human system development and cancer |
| title_sort | function and clinical implication of ythdf1 in the human system development and cancer |
| topic | YTHDF1 Embryonic development Stem cell Self-renewal Tumor Biomarker |
| url | https://doi.org/10.1186/s40364-023-00452-1 |
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