Exposure–Response Analysis of the Sodium–Glucose Cotransporter-2 Inhibitors Dapagliflozin and Empagliflozin on Kidney Hemodynamics in Patients with Type 2 Diabetes

Exposure–Response Analysis of the Sodium–Glucose Cotransporter-2 Inhibitors Dapagliflozin and Empagliflozin on Kidney Hemodynamics in Patients with Type 2 Diabetes

Sodium–glucose cotransporter-2 (SGLT2) inhibitors improve markers for renal and cardiovascular outcomes in patients with and without type 2 diabetes (T2D). To assess whether individual differences in plasma drug exposure can explain inter-individual response variation, we characterized the exposure–...

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Bibliographic Details
Main Authors: Sjoukje van der Hoek, Jeroen V. Koomen, Erik J. M. van Bommel, Charlotte M. Mosterd, Rosalie A. Scholtes, Anne C. Hesp, Jasper Stevens, Daniel H. van Raalte, Hiddo J. L. Heerspink
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Journal of Personalized Medicine
Subjects:
SGLT2 inhibitors
dapagliflozin
empagliflozin
pharmacokinetics
pharmacodynamics
renal hemodynamics
Online Access:https://www.mdpi.com/2075-4426/13/5/747

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https://www.mdpi.com/2075-4426/13/5/747

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