HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles
Bauzá-Martinez et al. analyzed the HLA-I peptide ligandome in extracellular vesicles (EVs) from an EBV-immortalized B cell line, JY, and compare HLA-I-binding peptides recovered from EVs to those recovered from whole-cells. The authors report an enrichment for HLA-B-binding peptides and for post-tra...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02364-y |
| _version_ | 1819194890357047296 |
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| author | Julia Bauzá-Martinez Albert J. R. Heck Wei Wu |
| author_facet | Julia Bauzá-Martinez Albert J. R. Heck Wei Wu |
| author_sort | Julia Bauzá-Martinez |
| collection | DOAJ |
| description | Bauzá-Martinez et al. analyzed the HLA-I peptide ligandome in extracellular vesicles (EVs) from an EBV-immortalized B cell line, JY, and compare HLA-I-binding peptides recovered from EVs to those recovered from whole-cells. The authors report an enrichment for HLA-B-binding peptides and for post-translationally modified cysteinylated peptides in EVs as compared to whole-cells. |
| first_indexed | 2024-12-23T02:04:03Z |
| format | Article |
| id | doaj.art-fbaffa91552645889971ca88dba9c128 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-23T02:04:03Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-fbaffa91552645889971ca88dba9c1282022-12-21T18:03:55ZengNature PortfolioCommunications Biology2399-36422021-07-014111110.1038/s42003-021-02364-yHLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesiclesJulia Bauzá-Martinez0Albert J. R. Heck1Wei Wu2Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht UniversityBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht UniversityBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht UniversityBauzá-Martinez et al. analyzed the HLA-I peptide ligandome in extracellular vesicles (EVs) from an EBV-immortalized B cell line, JY, and compare HLA-I-binding peptides recovered from EVs to those recovered from whole-cells. The authors report an enrichment for HLA-B-binding peptides and for post-translationally modified cysteinylated peptides in EVs as compared to whole-cells.https://doi.org/10.1038/s42003-021-02364-y |
| spellingShingle | Julia Bauzá-Martinez Albert J. R. Heck Wei Wu HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles Communications Biology |
| title | HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles |
| title_full | HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles |
| title_fullStr | HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles |
| title_full_unstemmed | HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles |
| title_short | HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles |
| title_sort | hla b and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles |
| url | https://doi.org/10.1038/s42003-021-02364-y |
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