The blunted vascular endothelial growth factor-A (VEGF-A) response to high-altitude hypoxia and genetic variants in the promoter region of the VEGFA gene in Sherpa highlanders

The blunted vascular endothelial growth factor-A (VEGF-A) response to high-altitude hypoxia and genetic variants in the promoter region of the VEGFA gene in Sherpa highlanders

Background Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitudes, which may be achieved by mechanisms promoting microcirculatory blood flow and capillary density at high altitudes for restoring oxygen supply to tissues. Vascular endothelial growth factors (VEGFs) are im...

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Bibliographic Details
Main Authors: Yunden Droma, Masayuki Hanaoka, Takumi Kinjo, Nobumitsu Kobayashi, Masanori Yasuo, Yoshiaki Kitaguchi, Masao Ota
Format: Article
Language:English
Published: PeerJ Inc. 2022-08-01
Series:PeerJ
Subjects:
Genetic adaptation
High altitude
Hypoxia
Vascular endothelial growth factor
Sherpa highlanders
Online Access:https://peerj.com/articles/13893.pdf

Internet

https://peerj.com/articles/13893.pdf

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