Potential Hypoglycemic and Antilipidemic Activity of Polyphenols from <i>Passiflora ligularis</i> (Granadilla)
The consumption of fruits or by-products from plants of the Passifloraceae family has been associated with multiple health and nutritional benefits, due to their phenolic compound content. Likewise, the effects of polyphenols from <i>Camellia sinensis</i> (green tea) have been explored a...
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/8/3551 |
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| author | Jaime Angel-Isaza Juan Carlos Carmona-Hernandez Clara Helena González-Correa William Vicente Narváez-Solarte |
| author_facet | Jaime Angel-Isaza Juan Carlos Carmona-Hernandez Clara Helena González-Correa William Vicente Narváez-Solarte |
| author_sort | Jaime Angel-Isaza |
| collection | DOAJ |
| description | The consumption of fruits or by-products from plants of the Passifloraceae family has been associated with multiple health and nutritional benefits, due to their phenolic compound content. Likewise, the effects of polyphenols from <i>Camellia sinensis</i> (green tea) have been explored and are considered a reference for different biological actions of these bioactive substances. This study compared the hypoglycemic and antilipemic activity of polyphenol-rich extracts of <i>Passiflora ligularis</i> Juss (passion fruit) and <i>Camellia sinensis</i> (green tea) given to a group of Wistar rats induced to be overweight. The individuals were subjected to three doses of supplementation of both sources of polyphenols in the drinking water. An additional group without polyphenol supplementation served as a control group. Water consumption, weight gain, glycemia, cholesterol, serum triglycerides and percentage of fecal ethereal extracts were analyzed. Although <i>Passiflora ligularis</i> Juss had five times less polyphenol content than <i>Camellia sinensis</i>, rats fed doses of 2.5 and 3.0 g/L <i>Passiflora ligularis</i> Juss showed reduced glycemia by 16%, suggesting an antiglycemic activity similar to that of <i>Camellia sinensis</i>. On the other hand, higher doses of polyphenols from <i>Passiflora ligularis</i> Juss and <i>Camellia sinensis</i> significantly reduced triglyceride levels (<i>p</i> = 0.05) by more than 17% compared to the unsupplemented control group. The polyphenol-rich extracts produced effective inhibitory activity of lipemic metabolites with a reduction in the percentage of fecal lipids (<i>p</i> < 0.05), with no side effects on liver tissue. The 3.0 g/L dose produced the best result on signs of metabolic syndrome associated with excess weight. Polyphenols extracted from fresh Colombian passion fruit showed the potential to decrease metabolic syndrome risk factors in a murine model. |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:42:06Z |
| publishDate | 2023-04-01 |
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| spelling | doaj.art-fbb0a48046a546489bab2d1aa2df3bbe2023-11-17T20:40:37ZengMDPI AGMolecules1420-30492023-04-01288355110.3390/molecules28083551Potential Hypoglycemic and Antilipidemic Activity of Polyphenols from <i>Passiflora ligularis</i> (Granadilla)Jaime Angel-Isaza0Juan Carlos Carmona-Hernandez1Clara Helena González-Correa2William Vicente Narváez-Solarte3Research Group on Nutrition, Metabolism and Food Security (NUTRIMESA), Universidad de Caldas, Manizales 170001, ColombiaMedical Research Group, Metabolism-Nutrition-Polyphenols (MeNutrO), Universidad de Manizales, Manizales 170004, ColombiaResearch Group on Nutrition, Metabolism and Food Security (NUTRIMESA), Universidad de Caldas, Manizales 170001, ColombiaResearch Group on Nutrition, Metabolism and Food Security (NUTRIMESA), Universidad de Caldas, Manizales 170001, ColombiaThe consumption of fruits or by-products from plants of the Passifloraceae family has been associated with multiple health and nutritional benefits, due to their phenolic compound content. Likewise, the effects of polyphenols from <i>Camellia sinensis</i> (green tea) have been explored and are considered a reference for different biological actions of these bioactive substances. This study compared the hypoglycemic and antilipemic activity of polyphenol-rich extracts of <i>Passiflora ligularis</i> Juss (passion fruit) and <i>Camellia sinensis</i> (green tea) given to a group of Wistar rats induced to be overweight. The individuals were subjected to three doses of supplementation of both sources of polyphenols in the drinking water. An additional group without polyphenol supplementation served as a control group. Water consumption, weight gain, glycemia, cholesterol, serum triglycerides and percentage of fecal ethereal extracts were analyzed. Although <i>Passiflora ligularis</i> Juss had five times less polyphenol content than <i>Camellia sinensis</i>, rats fed doses of 2.5 and 3.0 g/L <i>Passiflora ligularis</i> Juss showed reduced glycemia by 16%, suggesting an antiglycemic activity similar to that of <i>Camellia sinensis</i>. On the other hand, higher doses of polyphenols from <i>Passiflora ligularis</i> Juss and <i>Camellia sinensis</i> significantly reduced triglyceride levels (<i>p</i> = 0.05) by more than 17% compared to the unsupplemented control group. The polyphenol-rich extracts produced effective inhibitory activity of lipemic metabolites with a reduction in the percentage of fecal lipids (<i>p</i> < 0.05), with no side effects on liver tissue. The 3.0 g/L dose produced the best result on signs of metabolic syndrome associated with excess weight. Polyphenols extracted from fresh Colombian passion fruit showed the potential to decrease metabolic syndrome risk factors in a murine model.https://www.mdpi.com/1420-3049/28/8/3551<i>Passiflora ligularis</i> (granadilla)<i>Camellia sinensis</i> (green tea)glucoselipidsmurine model |
| spellingShingle | Jaime Angel-Isaza Juan Carlos Carmona-Hernandez Clara Helena González-Correa William Vicente Narváez-Solarte Potential Hypoglycemic and Antilipidemic Activity of Polyphenols from <i>Passiflora ligularis</i> (Granadilla) Molecules <i>Passiflora ligularis</i> (granadilla) <i>Camellia sinensis</i> (green tea) glucose lipids murine model |
| title | Potential Hypoglycemic and Antilipidemic Activity of Polyphenols from <i>Passiflora ligularis</i> (Granadilla) |
| title_full | Potential Hypoglycemic and Antilipidemic Activity of Polyphenols from <i>Passiflora ligularis</i> (Granadilla) |
| title_fullStr | Potential Hypoglycemic and Antilipidemic Activity of Polyphenols from <i>Passiflora ligularis</i> (Granadilla) |
| title_full_unstemmed | Potential Hypoglycemic and Antilipidemic Activity of Polyphenols from <i>Passiflora ligularis</i> (Granadilla) |
| title_short | Potential Hypoglycemic and Antilipidemic Activity of Polyphenols from <i>Passiflora ligularis</i> (Granadilla) |
| title_sort | potential hypoglycemic and antilipidemic activity of polyphenols from i passiflora ligularis i granadilla |
| topic | <i>Passiflora ligularis</i> (granadilla) <i>Camellia sinensis</i> (green tea) glucose lipids murine model |
| url | https://www.mdpi.com/1420-3049/28/8/3551 |
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