In Silico Substrate-Binding Profiling for SARS-CoV-2 Main Protease (M<sup>pro</sup>) Using Hexapeptide Substrates

The SARS-CoV-2 main protease (M<sup>pro</sup>) is essential for the life cycle of the COVID-19 virus. It cleaves the two polyproteins at 11 positions to generate mature proteins for virion formation. The cleavage site on these polyproteins is known to be Leu-Gln↓(Ser/Ala/Gly). A range of...

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Bibliographic Details
Main Authors: Sophakama Zabo, Kevin Alan Lobb
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/15/7/1480