Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation

Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation

Bryonolic acid (BrA) is a pentacyclic triterpene present in several plants used in African traditional medicine such as Anisophyllea dichostyla R. Br. Here we investigated the in vitro anticancer properties of BrA. We report that BrA inhibits acyl-coA: cholesterol acyl transferase (ACAT) activity in...

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Bibliographic Details
Main Authors: Farid Khallouki, Robert Wyn Owen, Sandrine Silvente-Poirot, Marc Poirot
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Biomedicines
Subjects:
cholesterol
metabolism
cholesteryl esters
tumour promoter
ChEH
cancer cell
invasiveness
colony formation
Online Access:http://www.mdpi.com/2227-9059/6/1/21

Internet

http://www.mdpi.com/2227-9059/6/1/21

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