The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2

The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2

Summary: Transcription factor Nrf2 and its negative regulator Keap1 orchestrate a cytoprotective response against oxidative, metabolic, and inflammatory stress. Keap1 is a drug target, with several small molecules in drug development. Here, we show that the isoquinoline PRL-295 increased Keap1 therm...

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Bibliographic Details
Main Authors: Sharadha Dayalan Naidu, Takafumi Suzuki, Dina Dikovskaya, Elena V. Knatko, Maureen Higgins, Miu Sato, Miroslav Novak, José A. Villegas, Terry W. Moore, Masayuki Yamamoto, Albena T. Dinkova-Kostova
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:iScience
Subjects:
Biological sciences
Biochemistry
Molecular interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221016734

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http://www.sciencedirect.com/science/article/pii/S2589004221016734

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