FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells

FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells

Mutations and inactivation of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) are observed in 15%–25% of cases of human T cell acute lymphoblastic leukemia (T-ALL). Pten deletion induces myeloproliferative disorders (MPDs), acute myeloid leukemia (AML), and/or T-ALL in mice. Previou...

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Bibliographic Details
Main Authors: Dewen You, Junping Xin, Andrew Volk, Wei Wei, Rachel Schmidt, Gina Scurti, Sucha Nand, Eun-Kyoung Breuer, Paul C. Kuo, Peter Breslin, Ameet R. Kini, Michael I. Nishimura, Nancy J. Zeleznik-Le, Jiwang Zhang
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715002338

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http://www.sciencedirect.com/science/article/pii/S2211124715002338

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