Mechanistic models of α-synuclein homeostasis for Parkinson's disease: A blueprint for therapeutic intervention

Mechanistic models of α-synuclein homeostasis for Parkinson's disease: A blueprint for therapeutic intervention

Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, yet there is no disease-modifying therapy up to this date. The biological complexity underlying PD hampers the investigation of the principal contributors to its pathogenesis. In this context, mechanistic m...

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Bibliographic Details
Main Authors: Elena Righetti, Alice Antonello, Luca Marchetti, Enrico Domenici, Federico Reali
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Applied Mathematics and Statistics
Subjects:
Parkinson's disease
neurodegeneration
alpha-synuclein aggregation
protein degradation mechanisms
mathematical modeling
systems biology
Online Access:https://www.frontiersin.org/articles/10.3389/fams.2022.1060489/full

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https://www.frontiersin.org/articles/10.3389/fams.2022.1060489/full

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