Mechanistic models of α-synuclein homeostasis for Parkinson's disease: A blueprint for therapeutic intervention

Mechanistic models of α-synuclein homeostasis for Parkinson's disease: A blueprint for therapeutic intervention

Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, yet there is no disease-modifying therapy up to this date. The biological complexity underlying PD hampers the investigation of the principal contributors to its pathogenesis. In this context, mechanistic m...

Full description

Bibliographic Details
Main Authors:	Elena Righetti, Alice Antonello, Luca Marchetti, Enrico Domenici, Federico Reali
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Applied Mathematics and Statistics
Subjects:	Parkinson's disease neurodegeneration alpha-synuclein aggregation protein degradation mechanisms mathematical modeling systems biology
Online Access:	https://www.frontiersin.org/articles/10.3389/fams.2022.1060489/full

Similar Items

Editorial: The Protein Alpha-Synuclein: Its Normal Role (in Neurons) and Its Role in Disease
by: Ruth G. Perez
Published: (2020-02-01)

Alpha-Synuclein Aggregation in Parkinson's Disease
by: E. Srinivasan, et al.
Published: (2021-10-01)

The Prion-Like Spreading of Alpha-Synuclein in Parkinson’s Disease: Update on Models and Hypotheses
by: Asad Jan, et al.
Published: (2021-08-01)

Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease
by: Scarlet eGallegos, et al.
Published: (2015-03-01)

New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease
by: Guoxin Zhang, et al.
Published: (2018-11-01)

Temporal Evolution of Inflammation and Neurodegeneration With Alpha-Synuclein Propagation in Parkinson's Disease Mouse Model
by: Thuy Thi Lai, et al.
Published: (2021-10-01)

Are Therapies That Target α-Synuclein Effective at Halting Parkinson’s Disease Progression? A Systematic Review
by: Abbie T. Rodger, et al.
Published: (2023-07-01)

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
by: Carroll Rutherford Fields, et al.
Published: (2019-12-01)

Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease
by: Valentina Gilmozzi, et al.
Published: (2020-10-01)

The Close Encounter Between Alpha-Synuclein and Mitochondria
by: Mattia Vicario, et al.
Published: (2018-06-01)

Alpha-Synuclein Contribution to Neuronal and Glial Damage in Parkinson’s Disease
by: Kamil Saramowicz, et al.
Published: (2023-12-01)

Exosome release and neuropathology induced by α-synuclein: new insights into protective mechanisms of Drp1 inhibition
by: Rebecca Z. Fan, et al.
Published: (2019-11-01)

Subcellular localization of alpha-synuclein aggregates and their interaction with membranes
by: Fabiana Miraglia, et al.
Published: (2018-01-01)

Found in Translation: The Utility of <i>C. elegans</i> Alpha-Synuclein Models of Parkinson’s Disease
by: Anthony L. Gaeta, et al.
Published: (2019-03-01)

Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association
by: Maxime Teixeira, et al.
Published: (2021-09-01)

Alpha-synuclein as a biomarker of Parkinson’s disease
by: S. N. Pchelina
Published: (2017-02-01)

Targeting α-synuclein for PD Therapeutics: A Pursuit on All Fronts
by: Margaux Teil, et al.
Published: (2020-03-01)

The Impact of <i>SNCA</i> Variations and Its Product Alpha-Synuclein on Non-Motor Features of Parkinson’s Disease
by: Luca Magistrelli, et al.
Published: (2021-08-01)

Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation
by: Louise Berkhoudt Lassen, et al.
Published: (2022-11-01)

Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and Neurodegeneration with Brain Iron Accumulation disorders
by: Rachel M. Wise, et al.
Published: (2022-12-01)

LRRK2 and Protein Aggregation in Parkinson’s Disease: Insights From Animal Models
by: Dylan J. Dues, et al.
Published: (2020-07-01)

Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight
by: Mohammed Al-Azzani, et al.
Published: (2022-02-01)

α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration
by: Chiara Fecchio, et al.
Published: (2018-06-01)

Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay
by: Cristina Cariulo, et al.
Published: (2019-08-01)

Modeling α-Synuclein Propagation with Preformed Fibril Injections
by: Hyun Kyung Chung, et al.
Published: (2019-09-01)

Exosomal cell-to-cell transmission of alpha synuclein oligomers
by: Danzer Karin M, et al.
Published: (2012-08-01)

The effects of post-translational modifications on alpha-synuclein aggregation and immune cell activation in Parkinson’s disease
by: Zaina Khan, et al.
Published: (2023-10-01)

Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo
by: Antonio Dominguez-Meijide, et al.
Published: (2021-04-01)

Alpha-Synuclein in the Gastrointestinal Tract as a Potential Biomarker for Early Detection of Parkinson’s Disease
by: Dominika Fricova, et al.
Published: (2020-11-01)

Rationale for Therapeutic Silencing of Alpha-Synuclein in Parkinson’s Disease
by: Demetrius M. Maraganore
Published: (2011-05-01)

Interaction between Neuromelanin and Alpha-Synuclein in Parkinson’s Disease
by: Shengli Xu, et al.
Published: (2015-06-01)

Alpha-Synuclein-Specific Regulatory T Cells Ameliorate Parkinson’s Disease Progression in Mice
by: Seon-Young Park, et al.
Published: (2023-10-01)

Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson’s Disease
by: Maria Angela Samis Zella, et al.
Published: (2019-01-01)

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
by: Yaping Chu, et al.
Published: (2009-09-01)

Salivary alpha-synuclein (total and oligomeric form): potential biomarkers in Parkinson’s disease
by: Hala Shaheen, et al.
Published: (2020-02-01)

From the baker to the bedside: yeast models of Parkinson's disease
by: Regina Menezes, et al.
Published: (2015-07-01)

Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein Toxicity
by: Shamini Vijayakumaran, et al.
Published: (2015-07-01)

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
by: Ricardo Guerrero-Ferreira, et al.
Published: (2019-12-01)

Pathological Pathways and Alpha-Synuclein in Parkinson's Disease: A View from the Periphery
by: Milo Jarno Basellini, et al.
Published: (2023-02-01)

Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease
by: Daniel Kam Yin Chan, et al.
Published: (2017-12-01)