Mechanism-based and computational modeling of hydrogen sulfide biogenesis inhibition: interfacial inhibition

Abstract Hydrogen sulfide (H2S) is a gaseous signaling molecule that participates in various signaling functions in health and diseases. The tetrameric cystathionine γ-lyase (CSE) contributes to H2S biogenesis and several investigations provide evidence on the pharmacological modulation of CSE as a...

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Bibliographic Details
Main Authors: Laurent Le Corre, Dominique Padovani
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34405-3