Tyrosine Kinase Inhibitors Reduce NMDA NR1 Subunit Expression, Nuclear Translocation, and Behavioral Pain Measures in Experimental Arthritis

Tyrosine Kinase Inhibitors Reduce NMDA NR1 Subunit Expression, Nuclear Translocation, and Behavioral Pain Measures in Experimental Arthritis

In the lumbar spinal cord dorsal horn, release of afferent nerve glutamate activates the neurons that relay information about injury pain. Here, we examined the effects of protein tyrosine kinase (PTK) inhibition on NMDA receptor NR1 subunit protein expression and subcellular localization in an acut...

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Bibliographic Details
Main Authors: Karin N. Westlund, Ying Lu, Liping Zhang, Todd C. Pappas, Wen-Ru Zhang, Giulio Taglialatela, Sabrina L. McIlwrath, Terry A. McNearney
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
pain
membrane trafficking
inflammation
glutamate
central sensitization
genistein
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00440/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00440/full

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