FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism

FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism

Summary: Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that deletion of the FGF21 co-receptor βKlotho (Klb) from the brain produces mice that are unable to mount a physiological r...

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Bibliographic Details
Main Authors: Cristal M. Hill, Thomas Laeger, Madeleine Dehner, Diana C. Albarado, Blaise Clarke, Desiree Wanders, Susan J. Burke, J. Jason Collier, Emily Qualls-Creekmore, Samantha M. Solon-Biet, Stephen J. Simpson, Hans-Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719306333

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http://www.sciencedirect.com/science/article/pii/S2211124719306333

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