FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism
Summary: Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that deletion of the FGF21 co-receptor βKlotho (Klb) from the brain produces mice that are unable to mount a physiological r...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719306333 |
| _version_ | 1818323508054196224 |
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| author | Cristal M. Hill Thomas Laeger Madeleine Dehner Diana C. Albarado Blaise Clarke Desiree Wanders Susan J. Burke J. Jason Collier Emily Qualls-Creekmore Samantha M. Solon-Biet Stephen J. Simpson Hans-Rudolf Berthoud Heike Münzberg Christopher D. Morrison |
| author_facet | Cristal M. Hill Thomas Laeger Madeleine Dehner Diana C. Albarado Blaise Clarke Desiree Wanders Susan J. Burke J. Jason Collier Emily Qualls-Creekmore Samantha M. Solon-Biet Stephen J. Simpson Hans-Rudolf Berthoud Heike Münzberg Christopher D. Morrison |
| author_sort | Cristal M. Hill |
| collection | DOAJ |
| description | Summary: Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that deletion of the FGF21 co-receptor βKlotho (Klb) from the brain produces mice that are unable to mount a physiological response to protein restriction, an effect that is replicated by whole-body deletion of FGF21. Mice forced to consume a low-protein diet exhibit reduced growth, increased energy expenditure, and a resistance to diet-induced obesity, but the loss of FGF21 signaling in the brain completely abrogates that response. When given access to a higher protein alternative, protein-restricted mice exhibit a shift toward protein-containing foods, and central FGF21 signaling is essential for that response. FGF21 is an endocrine signal linking the liver and brain, which regulates adaptive, homeostatic changes in metabolism and feeding behavior during protein restriction. : Dietary protein restriction induces changes in macronutrient preference, energy expenditure, growth, and metabolism. Hill et al. show that deletion of the FGF21 co-receptor from the brain produces mice that are unable to mount a physiological response to dietary protein restriction. FGF21 acts in the brain to coordinate homeostatic responses to protein restriction. Keywords: dietary protein restriction, FGF21, Klb, central nervous system, macronutrient, nutrition |
| first_indexed | 2024-12-13T11:13:48Z |
| format | Article |
| id | doaj.art-fbc23e92f7fb44a2b7e2fd673a5fd932 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-13T11:13:48Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-fbc23e92f7fb44a2b7e2fd673a5fd9322022-12-21T23:48:40ZengElsevierCell Reports2211-12472019-06-01271029342947.e3FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and MetabolismCristal M. Hill0Thomas Laeger1Madeleine Dehner2Diana C. Albarado3Blaise Clarke4Desiree Wanders5Susan J. Burke6J. Jason Collier7Emily Qualls-Creekmore8Samantha M. Solon-Biet9Stephen J. Simpson10Hans-Rudolf Berthoud11Heike Münzberg12Christopher D. Morrison13Pennington Biomedical Research Center, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Baton Rouge, LA 70808, USAGeorgia State University, Atlanta, GA 30302, USAPennington Biomedical Research Center, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Baton Rouge, LA 70808, USACharles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, NSW 2006, AustraliaCharles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, NSW 2006, AustraliaPennington Biomedical Research Center, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Baton Rouge, LA 70808, USAPennington Biomedical Research Center, Baton Rouge, LA 70808, USA; Corresponding authorSummary: Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that deletion of the FGF21 co-receptor βKlotho (Klb) from the brain produces mice that are unable to mount a physiological response to protein restriction, an effect that is replicated by whole-body deletion of FGF21. Mice forced to consume a low-protein diet exhibit reduced growth, increased energy expenditure, and a resistance to diet-induced obesity, but the loss of FGF21 signaling in the brain completely abrogates that response. When given access to a higher protein alternative, protein-restricted mice exhibit a shift toward protein-containing foods, and central FGF21 signaling is essential for that response. FGF21 is an endocrine signal linking the liver and brain, which regulates adaptive, homeostatic changes in metabolism and feeding behavior during protein restriction. : Dietary protein restriction induces changes in macronutrient preference, energy expenditure, growth, and metabolism. Hill et al. show that deletion of the FGF21 co-receptor from the brain produces mice that are unable to mount a physiological response to dietary protein restriction. FGF21 acts in the brain to coordinate homeostatic responses to protein restriction. Keywords: dietary protein restriction, FGF21, Klb, central nervous system, macronutrient, nutritionhttp://www.sciencedirect.com/science/article/pii/S2211124719306333 |
| spellingShingle | Cristal M. Hill Thomas Laeger Madeleine Dehner Diana C. Albarado Blaise Clarke Desiree Wanders Susan J. Burke J. Jason Collier Emily Qualls-Creekmore Samantha M. Solon-Biet Stephen J. Simpson Hans-Rudolf Berthoud Heike Münzberg Christopher D. Morrison FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism Cell Reports |
| title | FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism |
| title_full | FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism |
| title_fullStr | FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism |
| title_full_unstemmed | FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism |
| title_short | FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism |
| title_sort | fgf21 signals protein status to the brain and adaptively regulates food choice and metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2211124719306333 |
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