Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag

Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag

Human BCA2/RNF115/Rabring7 (hBCA2) is a RING type E3 ubiquitin ligase with the ability of autoubiquitination or promoting protein ubiquitination. It also acts as a host restriction factor has BST2-dependent and BST2-independent antiviral activity to inhibit the release of HIV-1. In a previous study,...

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Bibliographic Details
Main Authors: Meng Qu, Weiran Wang, Weiting Li, Jiaming Cao, Xin Zhang, Chu Wang, Jiaxin Wu, Bin Yu, Haihong Zhang, Hui Wu, Wei Kong, Xianghui Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
host restriction factor
BCA2
NF-κB
transcription
HIV-1 Gag
FIV Gag
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01230/full

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https://www.frontiersin.org/article/10.3389/fmicb.2020.01230/full

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