Potentiation of PIEZO2 mechanically-activated currents in sensory neurons mediates vincristine-induced mechanical hypersensitivity

Potentiation of PIEZO2 mechanically-activated currents in sensory neurons mediates vincristine-induced mechanical hypersensitivity

Vincristine, a widely used chemotherapeutic agent for treating different cancer, often induces severe peripheral neuropathic pain. A common symptom of vincristine-induced peripheral neuropathic pain is mechanical allodynia and hyperalgesia. However, mechanisms underlying vincristine-induced mechanic...

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Bibliographic Details
Main Authors: Mingli Duan, Yurui Jia, Lifang Huo, Yiting Gao, Jia Wang, Wei Zhang, Zhanfeng Jia
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Vincristine
Peripheral neuropathic pain
Mechanical hypersensitivity
Dorsal root ganglion neurons
PIEZO2 mechanically-activated currents
Whole-cell patch-clamp recording
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001569

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http://www.sciencedirect.com/science/article/pii/S2211383523001569

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