Association of Common and Rare Genetic Variation in the 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Gene and Cataract Risk

Association of Common and Rare Genetic Variation in the 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Gene and Cataract Risk

Background Results from animal models and observational studies have raised concerns regarding the potential cataractogenic effects of statin treatment. We investigated whether common and rare genetic variants in HMGCR are associated with cataract risk, to gauge the likely long‐term effects of stati...

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Bibliographic Details
Main Authors: Jonas Ghouse, Gustav Ahlberg, Anne Guldhammer Skov, Henning Bundgaard, Morten S. Olesen
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
ADR
cataract
HMG‐CoA reductase
HMGCR
loss‐of‐function
statins
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.025361

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.122.025361

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