New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities

New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities

We identified novel dicarboximides that were selectively cytotoxic towards human leukemia cells. Using chemical and biological methods, we characterized the biological activity, identified cellular protein targets and defined the mechanism of action of the test dicarboximides. The reported IC<sub...

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Bibliographic Details
Main Authors: Marcin Cieślak, Julia Kaźmierczak-Barańska, Karolina Królewska-Golińska, Mariola Napiórkowska, Iga Stukan, Urszula Wojda, Barbara Nawrot
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
apoptosis
dicarboximides
anticancer compounds
cytotoxicity
leukemia
ABC50 (ABCf1)
protac (proteolysis targeting chimera)
Online Access:https://www.mdpi.com/2218-273X/9/9/446

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https://www.mdpi.com/2218-273X/9/9/446

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