CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation

CD47-targeted cancer immunogene therapy: Secreted SIRPα-Fc fusion protein eradicates tumors by macrophage and NK cell activation

CD47 protects healthy cells from macrophage attack by binding to signal regulatory protein α (SIRPα), while its upregulation in cancer prevents immune clearance. Systemic treatment with CD47 antibodies requires a weakened Fc-mediated effector function or lower CD47-binding affinity to prevent side e...

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Bibliographic Details
Main Authors: Magdalena Billerhart, Monika Schönhofer, Hemma Schueffl, Wolfram Polzer, Julia Pichler, Simon Decker, Alexander Taschauer, Julia Maier, Martina Anton, Sebastian Eckmann, Manuel Blaschek, Petra Heffeter, Haider Sami, Manfred Ogris
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
gene therapy
polyplex
transfection
immunogene therapy
Fc receptor
macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001339

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http://www.sciencedirect.com/science/article/pii/S2372770521001339

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