Engineering the Catalytic Properties of Two-Domain Laccase from <i>Streptomyces griseoflavus</i> Ac-993

Engineering the Catalytic Properties of Two-Domain Laccase from <i>Streptomyces griseoflavus</i> Ac-993

Laccases catalyze the oxidation of substrates with the concomitant reduction of oxygen to water. Recently, we found that polar residues located in tunnels leading to Cu2 and Cu3 ions control oxygen entrance (His 165) and proton transport (Arg 240) of two-domain laccase (2D) from <i>Streptomyce...

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Bibliographic Details
Main Authors: Ilya Kolyadenko, Anastasia Scherbakova, Kirill Kovalev, Azat Gabdulkhakov, Svetlana Tishchenko
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
two-domain laccases
crystal structures
site-directed mutagenesis
proton wire
substrate-binding site
catalytic activity
Online Access:https://www.mdpi.com/1422-0067/23/1/65

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https://www.mdpi.com/1422-0067/23/1/65

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