Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx

Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx

Introductions: Excessive mechanical stress is closely associated with cell death in various conditions. Exposure of chondrocytes to excessive mechanical loading leads to a catabolic response as well as exaggerated cell death. Ferroptosis is a recently identified form of cell death during cell aging...

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Bibliographic Details
Main Authors: Shaoyi Wang, Weiwei Li, Pengfei Zhang, Zihao Wang, Xiaoyuan Ma, Chuanju Liu, Krasimir Vasilev, Lei Zhang, Xiaocong Zhou, Liang Liu, John Hayball, Shuli Dong, Yuhua Li, Yuan Gao, Lei Cheng, Yunpeng Zhao
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Journal of Advanced Research
Subjects:
Chondrocytes
Osteoarthritis
Ferroptosis
Mechanical stress
Piezo1
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222000042

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http://www.sciencedirect.com/science/article/pii/S2090123222000042

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