Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH

Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH

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Abstract Background Exposure to the house dust mite Dermatophagoides pteronyssinus (D.p.) increases the risk for developing allergic diseases in humans and their best friends, the dogs. Here, we explored whether this allergenic mite via its enzymes may impact the cutaneous extracellular matrix (ECM)...

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Bibliographic Details
Main Authors: Kumiko Oida, Lukas Einhorn, Ina Herrmann, Lucia Panakova, Yvonne Resch, Susanne Vrtala, Gerlinde Hofstetter, Akane Tanaka, Hiroshi Matsuda, Erika Jensen-Jarolim
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:World Allergy Organization Journal
Subjects:
Dermatophagoides pteronyssinus
Allergens
Epithelial barrier
Extracellular matrix
Proteases
N-acetyl-β-hexosaminidase
Online Access:http://link.springer.com/article/10.1186/s40413-017-0154-3

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http://link.springer.com/article/10.1186/s40413-017-0154-3

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