Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer

Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer

Activation of an immune response is critical for the efficacy of cancer therapies. Here, the authors show that combination of ROCK inhibitor with chemotherapeutics that induce immunogenic cell death of cancer cells leads to increased dendritic cells’ maturation and synergistic CD8+ cytotoxic T cell...

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Bibliographic Details
Main Authors: Gi-Hoon Nam, Eun Jung Lee, Yoon Kyoung Kim, Yeonsun Hong, Yoonjeong Choi, Myung-Jeom Ryu, Jiwan Woo, Yakdol Cho, Dong June Ahn, Yoosoo Yang, Ick-Chan Kwon, Seung-Yoon Park, In-San Kim
Format: Article
Language:English
Published: Nature Portfolio 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04607-9

Internet

https://doi.org/10.1038/s41467-018-04607-9

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