H-Ras nanocluster stability regulates the magnitude of MAPK signal output.

H-Ras nanocluster stability regulates the magnitude of MAPK signal output.

H-Ras is a binary switch that is activated by multiple co-factors and triggers several key cellular pathways one of which is MAPK. The specificity and magnitude of downstream activation is achieved by the spatio-temporal organization of the active H-Ras in the plasma membrane. Upon activation, the G...

Full description

Bibliographic Details
Main Authors: Barak Rotblat, Liron Belanis, Hong Liang, Roni Haklai, Galit Elad-Zefadia, John F Hancock, Yoel Kloog, Sarah J Plowman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2916832?pdf=render

Internet

http://europepmc.org/articles/PMC2916832?pdf=render

Similar Items