Ubiquitin‐proteasome‐system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF

Ubiquitin‐proteasome‐system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF

Abstract Background Skeletal muscle (SM) alterations contribute to exercise intolerance in heart failure patients with preserved (HFpEF) or reduced (HFrEF) left ventricular ejection fraction (LVEF). Protein degradation via the ubiquitin‐proteasome‐system (UPS), nuclear apoptosis, and reduced mitocho...

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Bibliographic Details
Main Authors: Volker Adams, Sebastian Wunderlich, Norman Mangner, Jennifer Hommel, Katrin Esefeld, Stephan Gielen, Martin Halle, Øyvind Ellingsen, Emeline M. Van Craenenbroeck, Ulrik Wisløff, Burkert Pieske, Axel Linke, Ephraim B. Winzer
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:ESC Heart Failure
Subjects:
Heart failure
Diastolic heart failure
Skeletal muscle exercise
Ubiquitin‐proteasome system genetics
Atrophy
Mitochondria
Online Access:https://doi.org/10.1002/ehf2.13405

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