ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

Abstract Background Nuclear acetyl-CoA pools govern histone acetylation that controls synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer’s disease (AD). Nuclear acetyl-CoA pools are generated partially from local acetate that is metabolized by acetyl-CoA synthe...

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Bibliographic Details
Main Authors: Yingbin Lin, Anlan Lin, Lili Cai, Weibin Huang, Shanzhi Yan, Yuanxiang Wei, Xinglin Ruan, Wenting Fang, Xiaoman Dai, Jinbo Cheng, Jie Zhang, Wanjin Chen, Qinyong Ye, Xiaochun Chen, Jing Zhang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
ACSS2
Synaptic plasticity
Histone acetylation
Acetate
Glutamate receptors
Online Access:https://doi.org/10.1186/s13024-023-00625-4

Internet

https://doi.org/10.1186/s13024-023-00625-4

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