The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes

The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes

Summary: How the opportunistic Gram-negative pathogens of the genus Achromobacter interact with the innate immune system is poorly understood. Using three Achromobacter clinical isolates from two species, we show that the type 3 secretion system (T3SS) is required to induce cell death in human macro...

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Bibliographic Details
Main Authors: Keren Turton, Hannah J. Parks, Paulina Zarodkiewicz, Mohamad A. Hamad, Rachel Dwane, Georgiana Parau, Rebecca J. Ingram, Rebecca C. Coll, Clare E. Bryant, Miguel A. Valvano
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723010239

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http://www.sciencedirect.com/science/article/pii/S2211124723010239

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