Perinatal N(G)-Nitro-L-arginine methyl ester administration decreases anxiety- and depression-like behaviors in adult mice

Perinatal N(G)-Nitro-L-arginine methyl ester administration decreases anxiety- and depression-like behaviors in adult mice

ABSTRACT Objective: We hypothesized that perinatal manipulations of the nitrergic system would affect adult animal behaviors. Methods: We tested this hypothesis by perinatally administering N(G)-Nitro-L-arginine methyl ester (L-NAME), a non-specific antagonist of nitric oxide synthase for 15 days...

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Bibliographic Details
Main Authors: Raoni Conceição Dos-Santos, Cláudio da Silva-Almeida, Bruno Guimarães Marinho, Rodrigo Rodrigues da Conceição, Wellington da Silva Côrtes, Ragab Gaber Ahmed, Roberto Laureano-Melo
Format: Article
Language:English
Published: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2023-12-01
Series:Einstein (São Paulo)
Subjects:
Anxiety
Depression
NG-nitroarginine methyl ester
Nitric oxide
Pain perception
Mice
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082023000100243&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082023000100243&lng=en&tlng=en

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