Endoplasmic Reticulum Stress/Ca2+-Calmodulin-Dependent Protein Kinase/Signal Transducer and Activator of Transcription 3 Pathway Plays a Role in the Regulation of Cellular Zinc Deficiency in Myocardial Ischemia/Reperfusion Injury

Endoplasmic Reticulum Stress/Ca2+-Calmodulin-Dependent Protein Kinase/Signal Transducer and Activator of Transcription 3 Pathway Plays a Role in the Regulation of Cellular Zinc Deficiency in Myocardial Ischemia/Reperfusion Injury

Zinc homeostasis has been known to play a role in myocardial ischemia/reperfusion (I/R) injury, but the precise molecular mechanisms regulating the expression of ZIP transporters during reperfusion are still unclear. The aim of this study was to determine whether ER Stress/CaMKII/STAT3 pathway plays...

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Bibliographic Details
Main Authors: Huanhuan Zhao, Dan Liu, Qiumei Yan, Xiyun Bian, Jing Yu, Jingjing Wang, Xinxin Cheng, Zhelong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Physiology
Subjects:
zinc deficiency
ischemia/reperfusion (I/R) injury
ER stress
CaMKII
STAT3
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.736920/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.736920/full

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