H<sub>2</sub>O<sub>2</sub> Mediates VEGF- and Flow-Induced Dilations of Coronary Arterioles in Early Type 1 Diabetes: Role of Vascular Arginase and PI3K-Linked eNOS Uncoupling

H<sub>2</sub>O<sub>2</sub> Mediates VEGF- and Flow-Induced Dilations of Coronary Arterioles in Early Type 1 Diabetes: Role of Vascular Arginase and PI3K-Linked eNOS Uncoupling

In diabetes, the enzyme arginase is upregulated, which may compete with endothelial nitric oxide (NO) synthase (eNOS) for their common substrate L-arginine and compromise NO-mediated vasodilation. However, this eNOS uncoupling can lead to superoxide production and possibly vasodilator hydrogen perox...

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Bibliographic Details
Main Authors: Naris Thengchaisri, Lih Kuo, Travis W. Hein
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
coronary microvascular disease
endothelial dysfunction
nitric oxide
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/24/1/489

Internet

https://www.mdpi.com/1422-0067/24/1/489

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