In vitro characterization and preclinical immunogenicity of Typhax, a typhoid fever protein capsular matrix vaccine candidate

Typhax is an investigational typhoid fever vaccine candidate that was GMP manufactured applying Protein Capsular Matrix Vaccine (PCMV) technology. It consists of Vi polysaccharide antigen, derived from S. Typhi, non-covalently entrapped in a glutaraldehyde catalyzed cross-linked α-poly-L-lysine and...

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Bibliographic Details
Main Authors: Thomas J. Griffin, Ann Thanawastien, Robert T. Cartee, John J. Mekalanos, Kevin P. Killeen
Format: Article
Language:English
Published: Taylor & Francis Group 2019-06-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Online Access:http://dx.doi.org/10.1080/21645515.2019.1599674