Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of Synthetic Preimplantation Factor in Autoimmune Hepatitis

Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of Synthetic Preimplantation Factor in Autoimmune Hepatitis

Preimplantation factor (PIF) is an evolutionary conserved peptide secreted by viable embryos which promotes maternal tolerance without immune suppression. Synthetic PIF (sPIF) replicates native peptide activity. The aim of this study was to conduct the first‐in‐human trial of the safety, tolerabilit...

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Bibliographic Details
Main Authors: Christopher B. O’Brien, Eytan R. Barnea, Paul Martin, Cynthia Levy, Eden Sharabi, Kalyan R. Bhamidimarri, Eric Martin, Leopold Arosemena, Eugene R. Schiff
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2018-10-01
Series:Hepatology Communications
Online Access:https://doi.org/10.1002/hep4.1239

Internet

https://doi.org/10.1002/hep4.1239

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