Conjugation of VEGFR1/R2-targeting peptide with gold nanoparticles to enhance antiangiogenic and antitumoral activity

Conjugation of VEGFR1/R2-targeting peptide with gold nanoparticles to enhance antiangiogenic and antitumoral activity

Abstract Background Inhibition of tumor angiogenesis through simultaneous targeting of vascular endothelial growth factor receptor (VEGFR)-1 and -2 is highly efficacious. An antagonist peptide of VEGFA/VEGFB, referred to as VGB3, can recognize and neutralize both VEGFR1 and VEGFR2 on the endothelial...

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Bibliographic Details
Main Authors: Pegah Zanjanchi, S. Mohsen Asghari, Hassan Mohabatkar, Mostafa Shourian, Mehdi Shafiee Ardestani
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Nanobiotechnology
Subjects:
Gold nanoparticles
Peptide
VEGFR1
VEGFR2
Tumor growth
Signaling pathways
Online Access:https://doi.org/10.1186/s12951-021-01198-4

Internet

https://doi.org/10.1186/s12951-021-01198-4

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