Pharmacophore-based discovery of 2-(phenylamino)aceto-hydrazides as potent eosinophil peroxidase (EPO) inhibitors

Pharmacophore-based discovery of 2-(phenylamino)aceto-hydrazides as potent eosinophil peroxidase (EPO) inhibitors

There is an increasing interest in developing novel eosinophil peroxidase (EPO) inhibitors, in order to provide new treatment strategies against chronic inflammatory and neurodegenerative diseases caused by eosinophilic disorder. Within this study, a ligand-based pharmacophore model for EPO inhibito...

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Bibliographic Details
Main Authors: Daniela Schuster, Martina Zederbauer, Thierry Langer, Andreas Kubin, Paul G. Furtmüller
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Eosinophil peroxidase inhibitors
2-(phenylamino)aceto-hydrazides derivatives
mechanism of inhibition
structure-activity-relationship
pre-steady-state kinetics
Online Access:http://dx.doi.org/10.1080/14756366.2018.1512598

Internet

http://dx.doi.org/10.1080/14756366.2018.1512598

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