CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors

CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors

Abstract Background High-grade serous ovarian carcinomas (HGSCs) are a heterogeneous subtype of epithelial ovarian cancers and include serous cancers arising in the fallopian tube and peritoneum. These cancers are now subdivided into homologous recombination repair (HR)-deficient and proficient subg...

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Bibliographic Details
Main Authors: Xue Lu, Yaowu He, Rebecca L. Johnston, Devathri Nanayakarra, Sivanandhini Sankarasubramanian, J. Alejandro Lopez, Michael Friedlander, Murugan Kalimutho, John D. Hooper, Prahlad V. Raninga, Kum Kum Khanna
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
High-grade serous ovarian carcinomas
SSRP1
PARP inhibitor
CBL0137
Homologous recombination
Online Access:https://doi.org/10.1186/s13046-022-02570-4

Internet

https://doi.org/10.1186/s13046-022-02570-4

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