Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation
Eukaryotic cells modulate their metabolism by organizing metabolic components in response to varying nutrient availability and energy demands. In rat axons, mitochondria respond to glucose levels by halting active transport in high glucose regions. We employ quantitative modeling to explore physical...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/40986 |
| _version_ | 1811200792624889856 |
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| author | Anamika Agrawal Gulcin Pekkurnaz Elena F Koslover |
| author_facet | Anamika Agrawal Gulcin Pekkurnaz Elena F Koslover |
| author_sort | Anamika Agrawal |
| collection | DOAJ |
| description | Eukaryotic cells modulate their metabolism by organizing metabolic components in response to varying nutrient availability and energy demands. In rat axons, mitochondria respond to glucose levels by halting active transport in high glucose regions. We employ quantitative modeling to explore physical limits on spatial organization of mitochondria and localized metabolic enhancement through regulated stopping of processive motion. We delineate the role of key parameters, including cellular glucose uptake and consumption rates, that are expected to modulate mitochondrial distribution and metabolic response in spatially varying glucose conditions. Our estimates indicate that physiological brain glucose levels fall within the limited range necessary for metabolic enhancement. Hence mitochondrial localization is shown to be a plausible regulatory mechanism for neuronal metabolic flexibility in the presence of spatially heterogeneous glucose, as may occur in long processes of projection neurons. These findings provide a framework for the control of cellular bioenergetics through organelle trafficking. |
| first_indexed | 2024-04-12T02:09:39Z |
| format | Article |
| id | doaj.art-fc11758b441a4f8e984fd308ec8cda08 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:09:39Z |
| publishDate | 2018-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-fc11758b441a4f8e984fd308ec8cda082022-12-22T03:52:27ZengeLife Sciences Publications LtdeLife2050-084X2018-12-01710.7554/eLife.40986Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulationAnamika Agrawal0https://orcid.org/0000-0002-1213-2321Gulcin Pekkurnaz1Elena F Koslover2https://orcid.org/0000-0003-4139-9209Department of Physics, University of California, San Diego, San Diego, United StatesSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, San Diego, United StatesDepartment of Physics, University of California, San Diego, San Diego, United StatesEukaryotic cells modulate their metabolism by organizing metabolic components in response to varying nutrient availability and energy demands. In rat axons, mitochondria respond to glucose levels by halting active transport in high glucose regions. We employ quantitative modeling to explore physical limits on spatial organization of mitochondria and localized metabolic enhancement through regulated stopping of processive motion. We delineate the role of key parameters, including cellular glucose uptake and consumption rates, that are expected to modulate mitochondrial distribution and metabolic response in spatially varying glucose conditions. Our estimates indicate that physiological brain glucose levels fall within the limited range necessary for metabolic enhancement. Hence mitochondrial localization is shown to be a plausible regulatory mechanism for neuronal metabolic flexibility in the presence of spatially heterogeneous glucose, as may occur in long processes of projection neurons. These findings provide a framework for the control of cellular bioenergetics through organelle trafficking.https://elifesciences.org/articles/40986intracellular transportreaction-diffusionneural metabolismmetabolic regulationmitochondrial trafficking |
| spellingShingle | Anamika Agrawal Gulcin Pekkurnaz Elena F Koslover Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation eLife intracellular transport reaction-diffusion neural metabolism metabolic regulation mitochondrial trafficking |
| title | Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation |
| title_full | Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation |
| title_fullStr | Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation |
| title_full_unstemmed | Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation |
| title_short | Spatial control of neuronal metabolism through glucose-mediated mitochondrial transport regulation |
| title_sort | spatial control of neuronal metabolism through glucose mediated mitochondrial transport regulation |
| topic | intracellular transport reaction-diffusion neural metabolism metabolic regulation mitochondrial trafficking |
| url | https://elifesciences.org/articles/40986 |
| work_keys_str_mv | AT anamikaagrawal spatialcontrolofneuronalmetabolismthroughglucosemediatedmitochondrialtransportregulation AT gulcinpekkurnaz spatialcontrolofneuronalmetabolismthroughglucosemediatedmitochondrialtransportregulation AT elenafkoslover spatialcontrolofneuronalmetabolismthroughglucosemediatedmitochondrialtransportregulation |