A conserved switch controls virulence, sporulation, and motility in C. difficile.

Spore formation is required for environmental survival and transmission of the human enteropathogenic Clostridioides difficile. In all bacterial spore formers, sporulation is regulated through activation of the master response regulator, Spo0A. However, the factors and mechanisms that directly regul...

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Bibliographic Details
Main Authors: Michael A DiCandia, Adrianne N Edwards, Ysabella B Alcaraz, Marcos P Monteiro, Cheyenne D Lee, Germán Vargas Cuebas, Pritha Bagchi, Shonna M McBride
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012224&type=printable