Tissue Damage, Not Infection, Triggers Hepatic Unfolded Protein Response in an Experimental Rat Peritonitis Model

Tissue Damage, Not Infection, Triggers Hepatic Unfolded Protein Response in an Experimental Rat Peritonitis Model

BackgroundAbdominal surgery is an efficient treatment of intra-abdominal sepsis. Surgical trauma and peritoneal infection lead to the activation of multiple pathological pathways. The liver is particularly susceptible to injury under septic conditions. Liver function is impaired when pathological co...

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Bibliographic Details
Main Authors: Andrea Müllebner, Anna Herminghaus, Ingrid Miller, Martina Kames, Andreia Luís, Olaf Picker, Inge Bauer, Andrey V. Kozlov, Johanna Catharina Duvigneau
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Medicine
Subjects:
sepsis
systemic inflammatory response syndrome (SIRS)
ER stress
surgical trauma
colon ascendens stent peritonitis (CASP)
unfolded protein response
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.785285/full

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https://www.frontiersin.org/articles/10.3389/fmed.2022.785285/full

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