Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes

Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes

Abstract Genome-wide association studies have identified numerous loci with allelic associations to Type 1 Diabetes (T1D) risk. Most disease-associated variants are enriched in regulatory sequences active in lymphoid cell types, suggesting that lymphocyte gene expression is altered in T1D. Here we a...

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Main Authors: Jeremy R. B. Newman, S. Alice Long, Cate Speake, Carla J. Greenbaum, Karen Cerosaletti, Stephen S. Rich, Suna Onengut-Gumuscu, Lauren M. McIntyre, Jane H. Buckner, Patrick Concannon
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05327-7

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https://doi.org/10.1038/s42003-023-05327-7

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