Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells.

Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells.

Here, we document that persistent mitochondria DNA (mtDNA) damage due to mitochondrial overexpression of the Y147A mutant uracil-N-glycosylase as well as mitochondrial overexpression of bacterial Exonuclease III or Herpes Simplex Virus protein UL12.5M185 can induce a complete loss of mtDNA (ρ0 pheno...

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Bibliographic Details
Main Authors: Domenico Spadafora, Nataliya Kozhukhar, Vladimir N Chouljenko, Konstantin G Kousoulas, Mikhail F Alexeyev
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4852919?pdf=render

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http://europepmc.org/articles/PMC4852919?pdf=render

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