Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCT

Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCT

Background: Microvascular obstruction commonly affects patients with acute ST-segment elevation myocardial infarction and is independently associated with adverse outcomes. Objective: To determine whether or not a strategy involving low-dose intracoronary fibrinolytic therapy infused early after cor...

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Bibliographic Details
Main Authors: Peter J McCartney, Hany Eteiba, Annette M Maznyczka, Margaret McEntegart, John P Greenwood, Douglas F Muir, Saqib Chowdhary, Anthony H Gershlick, Clare Appleby, James M Cotton, Andrew Wragg, Nick Curzen, Keith G Oldroyd, Mitchell Lindsay, J Paul Rocchiccioli, Aadil Shaukat, Richard Good, Stuart Watkins, Keith Robertson, Christopher Malkin, Lynn Martin, Lynsey Gillespie, Thomas J Ford, Mark C Petrie, Peter W Macfarlane, R Campbell Tait, Paul Welsh, Naveed Sattar, Robin A Weir, Keith A Fox, Ian Ford, Alex McConnachie, Colin Berry
Format: Article
Language:English
Published: NIHR Journals Library 2020-11-01
Series:Efficacy and Mechanism Evaluation
Subjects:
st elevation myocardial infarction
myocardial reperfusion fibrinolysis
thrombolytic therapy
coronary vessels
percutaneous coronary intervention
angioplasty, balloon, coronary
tissue plasminogen activator
medical futility
follow-up studies
magnetic resonance imaging
heart failure
stents
Online Access:https://doi.org/10.3310/eme07050

Internet

https://doi.org/10.3310/eme07050

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