Single-cell protein activity analysis reveals a novel subpopulation of chondrocytes and the corresponding key master regulator proteins associated with anti-senescence and OA progression

Single-cell protein activity analysis reveals a novel subpopulation of chondrocytes and the corresponding key master regulator proteins associated with anti-senescence and OA progression

BackgroundOsteoarthritis (OA) is a prevalent senescence-related disease with substantial joint pain, loss of joint function, and cartilage degeneration. Because of the paucity of single-cell studies of OA and the gene dropout problem of single-cell RNA sequencing, it is difficult to acquire an in-de...

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Bibliographic Details
Main Authors: Zhao Guang, Zhang Min, Li Jun-Tan, Dou Tian-Xu, Gao Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
osteoarthritis
chondrocyte
protein activity inference
single-cell RNA sequencing
senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1077003/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1077003/full

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