Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys

Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys

Abstract Background Inducing brain ATP-binding cassette 1 (ABCA1) activity in Alzheimer’s disease (AD) mouse models is associated with improvement in AD pathology. The purpose of this study was to investigate the effects of the ABCA1 agonist peptide CS-6253 on amyloid-β peptides (Aβ) and lipoprotein...

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Bibliographic Details
Main Authors: Sasan D. Noveir, Bilal E. Kerman, Haotian Xian, Cristiana Meuret, Sabrina Smadi, Ashley E. Martinez, Johannes Johansson, Henrik Zetterberg, Bryan A. Parks, Zsuzsanna Kuklenyik, Wendy J. Mack, Jan O. Johansson, Hussein N. Yassine
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
ABCA1
Apolipoprotein E
Alzheimer’s disease
CS-6253
Online Access:https://doi.org/10.1186/s13195-022-01028-1

Internet

https://doi.org/10.1186/s13195-022-01028-1

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