Inhibition of miR-96-5p alleviates intervertebral disc degeneration by regulating the peroxisome proliferator-activated receptor γ/nuclear factor-kappaB pathway

Inhibition of miR-96-5p alleviates intervertebral disc degeneration by regulating the peroxisome proliferator-activated receptor γ/nuclear factor-kappaB pathway

Abstract Background Intervertebral disc degeneration (IDD) is the main pathogenesis of low back pain. MicroRNAs (miRNAs) have been found to exert regulatory function in IDD. This study aimed to investigate the effect and potential mechanism of miR-96-5p in IDD. Methods In vitro cell model of IDD was...

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Bibliographic Details
Main Authors: Xusheng Li, Qian Hou, Wenqi Yuan, Xuehua Zhan, Haifeng Yuan
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
MiR-96-5p
Peroxisome proliferator-activated receptor γ/nuclear factor-kappaB (PPARγ/NF-κB)
Intervertebral disc degeneration (IDD)
Inflammation
Extracellular matrix (ECM)
Online Access:https://doi.org/10.1186/s13018-023-04412-1

Internet

https://doi.org/10.1186/s13018-023-04412-1

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