Deciphering the structure of Arabidopsis thaliana 5-enol-pyruvyl-shikimate-3-phosphate synthase: An essential step toward the discovery of novel inhibitors to supersede glyphosate

Deciphering the structure of Arabidopsis thaliana 5-enol-pyruvyl-shikimate-3-phosphate synthase: An essential step toward the discovery of novel inhibitors to supersede glyphosate

Glyphosate interferes with plant aromatic metabolism through the inhibition of 5-enol-pyruvyl-shikimate-3-phosphate (EPSP) synthase [EPSPS, EC 2.5.1.19]. For this reason, EPSPS has been extensively studied in a vast array of organisms. This notwithstanding, up to date, the crystal structure of the p...

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Bibliographic Details
Main Authors: Milosz Ruszkowski, Giuseppe Forlani
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Enzyme features
EPSP synthase
Glyphosate
Protein dynamics
Conformational change
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022000952

Internet

http://www.sciencedirect.com/science/article/pii/S2001037022000952

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