BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation

BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation

Cathepsin K inhibitor (odanacatib; ODN) and cathepsin K knockdown (siRNA) enhance oxaliplatin-induced apoptosis through p53-dependent Bax upregulation. However, its underlying mechanisms remain unclear. In this study, we elucidated the mechanism behind enhancement of oxaliplatin-induced apoptosis by...

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Bibliographic Details
Main Authors: Seung Un Seo, Seon Min Woo, Seul Gi Lee, Min Yeong Kim, Hyun Shik Lee, Yung Hyun Choi, Sang Hyun Kim, Young-Chae Chang, Kyoung-jin Min, Taeg Kyu Kwon
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Redox Biology
Subjects:
Odanacatib
Bax
p53
Sp1
BAP1
Mitochondrial ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001082

Internet

http://www.sciencedirect.com/science/article/pii/S2213231722001082

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